By W. N. Aldridge (eds.)
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Extra info for A Symposium on Mechanisms of Toxicity
SPAAN, G. & KLUSSMANN, F. W. (1969). Pfliigers Arch. ges. , 312, 1 WERNER, G. & KUPERMAN, A. S. (1963). In Handbuch der Experimentellen Pharmakologie, vol. 15, ed. Koelle, G. , pp. 57Q-678. Berlin: Springer Verlag WoLTHUIS, 0. L. & MEETER, E. (1968). Eur. J. , 2, 387 ZETLER, G. (1968). Int. J. , 7, 325 STELTER, W. MECHANISM OF INHIBITION OF GLUTAMINE SYNTHETASE BY METHIONINE SULPHOXIMINE A. MEISTER, R. A. RONZIO, W. B. ROWE, J. D. GASS &S. L. N. RAO Department of Biochemistry, Cornell University Medical College, N.
Eur. J. , 4, 103 TIPTON, K. F. (1968b). Biochim. biophys. Acta, 159, 451 TIPTON, K. F. (1968c). Eur. J. , 5, 316 TIPTON, K. F. (1969). Biochem. , 18, 2559 TIPTON, K. F. & SPIRES, I. P. C. (1968). Biochem. , 17,2137 YouDIM, M. B. , CoLLINS, G. G. S. & SANDLER, M. (1969). , 223, 626 YoUDIM, M. B. H. & SouRKES, T. L. (1966). Can. J. , 44, 1397 ZELLER, E. A. (1951). In The Enzymes, vol. 2, Part 1, p. 536, ed. Sumner, J. B. , New York: Academic Press ZELLER, E. , BLANKSMA, L. , BURKARD, w. , PACHA, w.
The absence of shivering in the soman-treated hypothermic rats certainly hampered their capacity to withstand cold, but, whether this fully explains the 10 times greater fall in body temperature is questionable. A factor to be considered is that the cellular metabolism must already have been markedly reduced at the start of the exposure to cold, due to the fact that the body temperature at that moment was about 6oC below normal. This in itself reduces the capacity of the organism to overcome the effects of cold-stress.
A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)